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Which is Better: Hold-out or Full-sample Classifier Design

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Brun, M., Xu, Q., and Dougherty, E. R., EURASIP Journal on Bioinformatics and Systems Biology, Vol. 2008, Article ID 297945, 8 pages, doi:10.1155/2008/297945, April, 2008

Abstract

Is it better to design a classifier and estimate its error on the full sample or to design a classifier on a training subset and estimate its error on the holdout test subset? Full-sample design provides the better classifier; nevertheless, one might choose holdout with the hope of better error estimation. A conservative criterion to decide the best course is to aimat a classifier whose error is less than a given bound. Then the choice between full-sample and holdout designs depends on which possesses the smaller expected bound. Using this criterion, we examine the choice between holdout and several full-sample error estimators using covariance models and a patient-data model. Full-sample design consistently outperforms holdout design. The relation between the two designs is revealed via a decomposition of the expected bound into the sum of the expected true error and the expected conditional standard deviation of the true error.

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